Article (PDF Available) in The Yale journal of biology and medicine 88(2) · June . The author, Robert A. Weinberg, a stalwart in. Robert Weinberg The Biology of Cancer. Garland Science: New York. p. ISBN: (hardcover) US $ The Biology of Cancer by . Robert A. Weinberg. The Biology of Cancer. Robert A. Weinberg. The Biology of Cancer. First Edition. Chapter 9: p53 and Apoptosis: Master. Guardian and.
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Robert A. Weinberg. Figure The Science ). Metastatic cancer cells in bone marrow (Wright-Giemsa stain complex biological steps. Figure The. The Biology of Cancer. First Edition. Chapter 8: Garland Science Robert A. Weinberg effect of TGF-β. -Inactivation of Rb pathways in human cancer. Editorial Reviews. Review. "The book fulfills its purpose and is, indeed, a must- read for The Biology of Cancer, Second Edition - Kindle edition by Robert A. Weinberg. Download it once and read it on your Kindle device, PC, phones or tablets.
Professional Science Thoroughly updated and incorporating the most important advances in the fast-growing field of cancer biology, The Biology of Cancer, Second Edition, maintains all of its hallmark features admired by students, instructors, researchers, and clinicians around the world. The Biology of Cancer is a textbook for students studying the molecular and cellular bases of cancer at the undergraduate, graduate, and medical school levels. The principles of cancer biology are presented in an organized, cogent, and in-depth manner. The clarity of writing, supported by an extensive full-color art program and numerous pedagogical features, makes the book accessible and engaging. The information unfolds through the presentation of key experiments that give readers a sense of discovery and provide insights into the conceptual foundation underlying modern cancer biology. The new Second Edition has been comprehensively revised and updated to include major advances in cancer biology over the past six years.
In the Synopses and Prospects sections of each chapter, which is perhaps the most intellectually engaging feature of The Biology of Cancer, Prof. Weinberg brings together the key elements of the chapter and presents his thoughts on novel implications of the information presented and emerging challenges to investigators in the field.
I think for most readers or teachers, these sections are worth the price of admission!
All of these sections are bound to excite undergraduate and graduate students into the field. Also, this is the first textbook that I have seen that has an extensive glossary of acronyms for novices to keep track of the arcane lexicon of signaling proteins and transcription factors.
Each chapter ends with a set of 4—8 interesting and occasionally challenging Thought Questions. The first nine chapters takes the reader through the basic biochemical and cellular machinery relevant to cancer biology, starting with the early observations of the viral origins of animal sarcomas to the modern impact of tumor viruses in our understanding of the epigenesis of the cancer cell and then to oncoproteins and tumor suppressors and the biochemical signaling pathways that they impact.
Weinberg finishes this section with impact of oncoproteins and tumor suppressors on the control of the cell cycle and programmed cell death. While the fundamental approach to the science in this text is reductionist, Prof.
This book is rich in treasures for the novice or expert I would think. The plethora of diagrams, pathway maps, histology, and collections of highly informative tables is a gold mine for anyone teaching cell biology and cancer.
There are countless fascinating sidebars throughout the text, and if that were not enough, there is a CD that contains over 50 additional sidebar discussions. The CD also contains most of the important figures of the text in PowerPoint format, and some additional lectures in MP3 format.
Two phenomena in cancer lore were missing from The Biology of Cancer: 1 the Warburg Effect, wherein aerobic glycolysis in cancer cells seems to signal some dysfunction in mitochondria function; and 2 the noninvasive behavior of malignant teratocarcinomas transplanted into blastocysts.
The latter observation, first documented by Beatrice Mintz, seems a peculiar case, perhaps irrelevant. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License, which permits for noncommercial use, distribution, and reproduction in any digital medium, provided the original work is properly cited and is not altered in any way.
The Biology of Cancer by Robert Weinberg is a textbook aimed at graduate biology and medical students. It covers the basic biology of cancer at the molecular and cellular level.
The book begins with a brief history of the field of cancer biology as it spawned from accelerated research after World War II and into the mids, when cancer biology really took off as an independent field of research.
The following chapters cover the basics of cell biology and explore how many of these mechanisms are altered in different types of cancer. The main aim of the book is to gather what has been discovered about cancer in the past 30 years and begin to distill this information into underlying laws and principles that emerge from the large amount of data collected.
The book does a great job in not only presenting the facts of what has been established but also highlighting the questions that remain in the field.
In a sense, the textbook is like a large collection of review articles covering everything from apoptosis to receptor signaling to mitosis and spindle assembly.
The book covers an immense amount of material and is best used as a reference to review the basic principles of different aspects of cancer biology. The book contains a CD-ROM that has many additional figures and tables in Powerpoint format and some movies that correspond to each chapter. In addition, like most textbooks, the end of each chapter contains study questions useful to evaluate understanding of the presented topic.
I would highly recommend this book to any graduate or medical student interested in reviewing the fundamentals of cancer biology.