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It was a white colored powder drug having melting point C.
Ibuprofen possesses analgesic and antipyretic activities. Its mode of action, like that of other NSAIDs, is not completely understood, but may be related to prostaglandin synthetase inhibition. Ethyl cellulose, polyvinyl pyrrolidone, polyethylene glycol and propylene glycol were received as a gift samples from Loba Chemicals, India.
Aluminium foil was used as a backing membrane. All the other solvents and chemicals were of analytical grade. Preparation of formulation with aluminium backed adhesive film method 1. Weighed quantity of ethylcellulose , , , mg , PVP , , , 90mg were dissolved in ethanol 4ml and kept for swelling upto 15 minutes.
The ibuprofen was dissolved in toluene 16ml and was added to polymeric solution. To the above PEG was added 4.
The contents were mixed for about 10 minute and sonicated to evolve the entrapped air 5. The above solution was poured into petridish with aluminium foil and allowed to evaporate the solvent for about 8 to 12 hours at room temperature.
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