Textbook of Biochemistry with Clinical. Correlations, Sixth Edition. Thomas M. Devlin, Editor, John Wiley & Sons, Inc.,. Hoboken, NJ, 1, pp., $, Thomas M. Devlin — 4th ed. . In this fourth edition of Textbook of Biochemistry With Clinical Correlations, the contributors have with six chapters on topics that comprise Physiological Chemistry, including cytochrome P enzymes and. Textbook of Biochemistry with Clinical Correlations, Sixth Edition. Thomas M. Devlin, ed. Hoboken, NJ: Wiley-Liss, John Wiley & Sons, , pp., $
|Language:||English, Spanish, French|
|ePub File Size:||27.40 MB|
|PDF File Size:||12.21 MB|
|Distribution:||Free* [*Sign up for free]|
by Devlin, Thomas M. biochemistry biochemistry Textbook of Biochemistry - For Medical Students, 6th Edition Textbook Equity Edition Vol 2. -JDFOTF. Textbook of Biochemistry with Clinical Correlations (6th Edition). Edited by Thomas M. Devlin; Wiley‐Liss, Hoboken, New Jersey, , Request PDF on ResearchGate | Textbook of Biochemistry with Clinical Correlations, Sixth Edition. Thomas M. Devlin, ed. Hoboken, NJ: Wiley-Liss, John Wiley.
This is a magnificent text: large, comprehensive, up-to-date and exciting. As a multi-author treatise it does suffer somewhat from variability of style, but overall Dr Devlin is to be commended as editor for the uniformity of quality and point of view in this book. For a Medical School course 'Textbook of Biochemistry' has many things to commend it. Human biochemistry is stressed wherever possible, with other biochemical systems discussed only when necessary due to our current ignorance of human systems. The 'Clinical Correlations', brief, boxed descriptions of biochemical events in pathological states, are interesting and sure to demonstrate that biochemistry is indeed a 'relevant' study for the Medical Student.
The textbook has ample and well-colored diagrams throughout that are of the highest quality.
The diagrams provide a very important aid to understanding what are frequently complicated mechanisms and pathways. This is an excellent teaching volume, which could readily be used not only by undergraduates and graduate students but also by fellows in clinical chemistry training programs.
Skip to main content. Michael J. Previous Next. Back to top. In this issue. Thomas M.
Devlin, ed. Hoboken, NJ: ISBN Share This Article: Article Alerts. Citation Tools. Related Articles. Proteomics of Human Body Fluids. Visith Thongboonkerd, Editor. Humana Press, , pp.
Mitchell G. Scott, Ann M. Gronowski, and Charles S. And much of it will, after all, appear in other required coursework of the medical or biology student.
The editor suggests that this book could serve as an upper division or graduate-level biochemistry text. For students in these courses the book has some advantages and some major deficiencies. To me the major advantages are its clear presentation of the biochemistry of a single organism, particularly regulation and control, and the constant attention to correlating particular pathways to specific tissues.
I feel that most students are better served by gaining an integrated understanding of the workings of a single complete system, than they are by being inundated by scattered facts dealing with a myriad of organisms.
I also feel it is important for students to realize that tissues in eukaryotes are specialized, in biochemistry as well as function, and that biochemical integration often comes only at the whole organism level. I was also impressed with the various authors' concern that purported processes have been shown to occur under physiological conditions and at physiological concentrations.
How often in the past have we created fallacious models based on unrealistic in vitro experiments? The major deficiencies of this text are a complete lack of plant biochemistry, including photosynthesis, and the various important pathways lacking in humans, such as essential amino acid biosynthesis and vitamin biosynthesis.
For the nonmedical student this is important stuff. Most students, including medical students, would also benefit from problems at the ends of the chapters. Overall I recommend this book as a medical school text and as an excellent reference.
It has been very useful to me in preparing my own lectures for undergraduates. Richard A Paselk Convincing preclinical medical students of the importance of a sound grounding in basic biochemistry for understanding human disease and clinical medicine is often very difficult with the currently available biochemical textbooks.
Thomas Devlin and his twentyone co-authors aimed to produce a textbook for medical students in which biochemical events at the cellular level are related to physiological processes in the whole animal and the relevance of topics to disease problems is emphasised throughout.
These correlations cover a considerable range, describing the biochemistry of disease states, biochemical actions of antibiotics and drugs and use of biochemical tests in diagnosis. Often the same clinical condition, eg diabetes, thalassaemia, gout, is used to illustrate different points in separate chapters.
This approach is attractive and for the most part these correlations succeed, but there are some surprising omissions and others are rather contrived. Besides the clinical correlations there are other useful features particularly welcome for medical s t u d e n t s - the sections on metabolic interrelationships, nutrition, metabolism of individual tissues, pH regulation, gas transport and genetic engineering.
The basic biochemistry is sound and well-written, except for one or two chapters, and there is adequate crossreferencing. However, while this is an attractive book for medical students there are defects. Generally there is too much detail for British preclinical courses. The photographs and diagrams black-and-white only compare unfavourably with competing biochemistry books and the Index could be better for such a complex book where many topics cut across several sections.
If the proposed paper-bound edition January is very substantially cheaper, then it will be worth downloading. S J Higgins himself into the sort of muddle considered reprehensible in an undergraduate biochemistry student. The next paragraph tells us that a plot of reaction rate against substrate concentration allows the rate constants to be determined, but unfortunately the method of achieving this useful and remarkable feat is not given.
I have concentrated on the small part of the book that is concerned with what I know most about, because I feel that if a book cannot give a clear and accurate account of what I know already it is unwise to trust what it says about anything else. Perhaps the author is stronger on thermodynamics than on kinetics, but I doubt it.
It is not obvious, for example, that he has noticed that most biological processes occur at constant pressure in the liquid phase, rather than at constant volume in the gas phase. So when enthalpy and the Gibbs energy are mentioned at all they are treated as an afterthought and not as quantities that are central to the whole subject. The book is proudly described as a 'second, corrected and updated edition', though it contains virtually no references to modern experimental work in biology or biochemistry and refers, for example, to the unit membrane model of Danielli and Davson as 'generally accepted'.
What the book must have been like before it was updated beggars the imagination. Springer-Verlag, Berlin.
DM This book is intended for both physicists and nonphysicists, but I think that most biochemists will learn nothing from it and that physicists interested in applying their knowledge to biological systems would do better to learn something about biological systems first. When they have done so they will not need this book. Biophysics is a discipline that I approach with caution, because too often it seems to be a refuge for inadequate physicists who see themselves as missionaries among the head-hunters of humbler sciences.
Although I can understand little of what they write, when I do understand I often find incorrect or trivial ideas lurking in the thickets of pretentious mathematics. The first detailed section of the book is devoted to MichaelisMenten kinetics, a topic most biochemists are reasonably familiar with, but Schnakenberg's treatment is not illuminating. The general obscurity is partly the result of using unfamiliar and sometimes undefined symbolism, and I wonder what advantage J has over v as a symbol for reaction rate, for example.
The failure to explain things adequately in the text is more important, as is the number of elementary errors. The second equation in the book is dimensionally inconsistent, and the discussion of the justification for neglecting the reverse reaction in initial-rate studies is wrong.
One may neglect it if the product concentration is negligible, or if the relevant rate constant is zero, two possibilities that are completely independent, both logically and in practice: Chapman and Hall, London. The recent application of nucleic acid biochemistry in genetic engineering and its related disciplines has provided much new material to be taught in undergraduate courses.
At the same time the expansion in the treatment of this area of biochemistry in standard textbooks has proceeded, in certain cases, to a high level and recently several useful specialist paperbacks covering important topics such as genetic engineering have appeared and are clearly useful teaching material. Does the ninth edition of this book of eminent pedigree stand comparison with competitors in the market?
There is no doubt that this book will recommend itself to many, being a one-volume work covering well all aspects of the subject which one would expect to find in undergraduate courses from biosynthesis of nucleic acid precursors through structure and function of nucleic acids to the headier heights of the control of transcription and translation in prokaryotes and eukaryotes including a brief chapter on the enzymes and techniques employed in recombinant DNA research.
The standard of accuracy is very high, references are extensive and the index is good.